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Is Vitamin D Deficiency a Risk Factor in Hypertension Development?

Yıl 2015, Cilt: 4 Sayı: 1, 34 - 39, 10.07.2015

Azime Karakoç Kumsar , Feride Taşkın Yılmaz , Nermin Olgun

Öz

Vitamin D is an essential factor for homeostasis of calsium and phosphorus, but also contributes to the prevention of various autoimmune, cardiovascular and infectious diseases as a result of their antiinflammatory and immune modulatory properties and effects on cytokine levels. Renal, cerebrovascular and cardiovascular disease, which is a majör modifiable risk factor for hypertension, is considered as one of the major causes of death in the world. Recently, many studies are reported to berelationship between risk of hypertension with vitamin D deficiency. In this review, the effects of vitamin D on blood pressure and whether the effect of vitamin D deficiency in the development of hypertension will be discussed with current literatüre. This review will contribute to provide updated information for particulary nurses and all health professionals in the prevention and control of hypertension

Anahtar Kelimeler

Vitamin D hypertension blood pressure

Kaynakça

  • Akpınar P, İçağasıoğlu A (2012) D vitamininin yaşam kalitesi ile ilişkisi. Türk Osteoporoz Dergisi, 18(1): 13-18.
  • Arık S (2008) Hashimoto tiroiditinde 25 hidroksi D vitamini ve paratiroid hormon düzeyi. Yayımlanmamış Bakanlığı Göztepe Eğitim ve Araştırma Hastanesi, İstanbul. tezi, Sağlık
  • Anderson JL, May HT, Horne BD et al. (2010) Relation cardiovascular risk factors, disease status and incident events in a general healthcare population. Cardiology, 106(7): 963-968. deficiency to The American Journal of
  • Artaza JN, Mehrotra R, Norris KC (2009) Vitamin D and the cardiovascular system. Clin J Am Soc Nephrol, 4(9): 1515-1522.(doi: 10.2215 /CJN.02260409).
  • Boucher B (2011) Vitamin D In sufficiency and diabetes risks. Current Drug Targets, 12(1): 61-87.
  • Cheng S, Massaro JM, Fox CS et al. (2010) Adiposity, cardiometabolic risk and vitamin D status: The Framingham Heart Study. Diabetes, 59(1): 242-248.
  • Cosenso-Martin LN, Vilela-Martin JF (2011) Is there an association between vitamin D and hypertension? Recent Pat Cardiovasc Drug Discov, 6(2): 140-147.
  • Feneis JF, Arora RR (2010) Role of vitamin D in blood pressure homeostasis. Am J Ther, 17(6): 221-229.
  • Florez H, Troen BR (2011) Do vitamin D levels influence the risk of diabetes mellitus and play a role in healthier aging? J Am Geriatr Soc, 59(10): 1957-1959.
  • Forman JP, Curhan GC, Taylor EN (2008) Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension, 52(5): 828-832.
  • Forman JP, Bischoff-Ferrari HA, Willett WC et al. (2005) Vitamin D intake and risk of incident hypertension prospective cohort studies. Hypertension, 46(4): 676-682. from three large
  • Forman JP, Giovannucci E, Holmes MD et al. (2007) Plasma 25-Hydroxyvitamin D levels and risk of incident hypertension. Hypertension, 49(5): 1063-1069. (doi: 10.1161/Hypertensı- onaha.107.087288).
  • Goel LK, Lal H (2011) Role of vitamin D supple- mentation in hypertension. Indian J Clin Biochem, 26(1): 88–90.
  • Grant WB, Holick MF (2005) Benefits and requirements of vitamin D for optimal health: A review. Altern Med Rev, 10(2): 94-111.
  • Holick M (2008) Diabetes and the vitamin D connection. Current Diabetes Reports, 8(5): 393-398.
  • Holick MF (2013) The D-lightful vitamin D for health. J Med Biochem, 32(1): 1-10.
  • Jafari T, Paknahad Z (2014) Vitamin D and Hypertension. Zahedan J Res Med Sci, 16(6): 1-7.
  • Jameson JL, Weetman AP (2004) Tiroid bezi hastalıkları. (Çeviri editörü: Y. Sağlıker). Harrison İç Hastalıkları Prensipleri (15. Edisyon). Nobel Matbaacılık, İstanbul, s:2060- 2075.
  • Javed R, Malik SY, Yaqup S et al. (2012) Levels of 25-OH vitamin D in healthy asymptomatic adults: Pilot study. Pak J Med Res, July- September: 82-86.
  • Kavaric S, Vuksanovic M, Bozovic D et al. (2013) Body weight and waist circumference as predictors of vitamin D deficiency in patients with type 2 diabetes and cardiovascular disease. Vojnosanit Pregl, 70(2): 163-169.
  • Kim MK, Kang M, Won Oh K et al. (2010) The association of serum vitamin D level with presence of metabolic syndrome and hyperteso n in middle-aged Endocrinol (Oxf), 73(3): 330-338. Clin
  • Kota SK, Kota SK, Jammula S et al. (2011) Renin- angiotensin system activity in vitamin D defici ent, obese individuals with hypertension:An ur ban Indian study. Indian J Endocrinol Metab, 15(4): 395-401.
  • Kurşun ÖS (2008) Şişman çocuklarda D vitamini düzeyleri ve insülin direnci ile ilişkisinin araştırılması. Yayımlanmamış uzmanlık tezi, Trakya Üniversitesi Tıp Fakültesi, Edirne.
  • Kunutsor SK, Apekey TA (2013) Vitamin D and risk of future hypertension: Meta-analysis of 283.537 participants. Eur J Epidemiol, 28(3): 205-221. (DOI: 10.1007/s10654-013-9790-2).
  • Li YC, Qiao G, Uskokovic M et al. (2004) Vitamin D: A negative endocrine regulator of the renin– angiotensin system and blood pressure. J Ster Bio -chem Molec Biol, 89–90:387–392.
  • Lim S, Kim MJ, Choi SH t al. (2013) Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asiansubjects. Am J Clin Nutr, 97(3): 524-530.
  • Martin T, Campbell K (2011) Vitamin D and diabetes. Diabetes Spectrum, 24(2): 113-118.
  • Maxwell CS, Wood RJ (2011) Update on vitamin D and type 2 diabetes. Nutrition Reviews, 69(5): 291-295.
  • Mitri J, Muraru MD, Pittas AG (2011) Vitamin D and type 2 diabetes: a systematic review. European Journal of Clinical Nutrition, 65(9): 1005-1015.
  • Özkan B, Döneray H (2011) D vitamininin iskelet sistemi dışı etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi, 54(2): 99-119.
  • Parker J, Hashmi O, Dutton D et al. (2010) Levels of vitamin D and cardiometabolic disorders: Systematic Maturitas, 65(3): 225-236. meta-analysis.
  • Pavlovic D, Josipovic J, Pavlovic N (2011) Vitamin D and hypertension. Periodicum Biologorum, 113(3) :299-302.
  • Pearce SH, Cheetham TD (2010) Diagnosis and management of vitamin D deficiency. BMJ, 340.
  • Snijder MB, Lips P, Seidell JC et al. (2007) Vitamin D status and parathyroid hormone levels in relation to blood pressure: A population-based study in older men and women. J Intern Med, 261(6): 558-565.
  • Sung CC, Liao MT, Lu KC et al. (2012) Role of vitamin D in insulin resistance. Journal of Biomedicine and Biotechnology, Article ID 634195 (doi:10.1155/2012/634195).
  • Tamez H, Kalim S, Thadhani RI (2013) Does vitamin D modulate blood pressure?. Clinical Nephrology, 22(2): 204-209.
  • Tellioğlu A, Başaran S (2013) Güncel bilgiler ışığında vitamin D. Arşiv Kaynak Tarama Dergisi, 22(2): 259-271.
  • Ullah MI, Uwaifo GI, Nicholas WC et al. (2010) Does vitamin d deficiency cause hypertension? Current evidence from clinical studies and pot entialmechanisms.Int J Endocrinol. 2010: 579640.
  • Vacek JL, Vanga SR, Good M et al. (2012) Vitamin D deficiency and supplementation and relation to cardiovascular health. Am J Cardiol, 109:359–363.
  • Wang TJ, Pencina MJ, Booth SL et al. (2008) deficiency cardiovascular disease. Circulation, 117:503- 511. and risk of

VİTAMİN D EKSİKLİĞİ HİPERTANSİYON GELİŞİMİNDE BİR RİSK FAKTÖRÜ MÜ?

Yıl 2015, Cilt: 4 Sayı: 1, 34 - 39, 10.07.2015

Azime Karakoç Kumsar , Feride Taşkın Yılmaz , Nermin Olgun

Öz

Vitamin D’nin bilinen en temel görevi, kalsiyum ve fosfor konsantrasyonunu idame ettirmek olmasının yanında; antiinflamatuar, immünmodülatör özellikleri ve sitotin seviyeleri üzerine olası etkileri nedeniyle birçok otoimmün, kardiyovasküler ve enfeksiyon hastalığının önlenmesinde önemli rolleri de bulunmaktadır. Renal, serebrovasküler ve kardiyovasküler hastalıklar için majör değiştirilebilir risk faktörlerinden olan hipertansiyon, dünyada en önemli ölüm nedenlerinden biri olarak kabul edilmektedir. Son yıllarda farklı çalışmalarla, vitamin D’ nin hipertansiyon patogenezinde rol aldığını destekleyen veriler ortaya konulmuştur. Bu derlemede, vitamin D’ nin kan basıncı üzerindeki etkileri ile vitamin D eksikliğinin hipertansiyon gelişiminde etkisi olup olmadığı güncel literatür bilgisi doğrultusunda ele alınmıştır. Derleme, hipertansiyonun önlenmesinde ve kontrolünde başta hemşireler olmak üzere tüm sağlık profesyonellerine güncel bilgi sunması açısından katkı sağlayacaktır.

Anahtar Kelimeler

Vitamin D hipertansiyon kan basıncı

Kaynakça

  • Akpınar P, İçağasıoğlu A (2012) D vitamininin yaşam kalitesi ile ilişkisi. Türk Osteoporoz Dergisi, 18(1): 13-18.
  • Arık S (2008) Hashimoto tiroiditinde 25 hidroksi D vitamini ve paratiroid hormon düzeyi. Yayımlanmamış Bakanlığı Göztepe Eğitim ve Araştırma Hastanesi, İstanbul. tezi, Sağlık
  • Anderson JL, May HT, Horne BD et al. (2010) Relation cardiovascular risk factors, disease status and incident events in a general healthcare population. Cardiology, 106(7): 963-968. deficiency to The American Journal of
  • Artaza JN, Mehrotra R, Norris KC (2009) Vitamin D and the cardiovascular system. Clin J Am Soc Nephrol, 4(9): 1515-1522.(doi: 10.2215 /CJN.02260409).
  • Boucher B (2011) Vitamin D In sufficiency and diabetes risks. Current Drug Targets, 12(1): 61-87.
  • Cheng S, Massaro JM, Fox CS et al. (2010) Adiposity, cardiometabolic risk and vitamin D status: The Framingham Heart Study. Diabetes, 59(1): 242-248.
  • Cosenso-Martin LN, Vilela-Martin JF (2011) Is there an association between vitamin D and hypertension? Recent Pat Cardiovasc Drug Discov, 6(2): 140-147.
  • Feneis JF, Arora RR (2010) Role of vitamin D in blood pressure homeostasis. Am J Ther, 17(6): 221-229.
  • Florez H, Troen BR (2011) Do vitamin D levels influence the risk of diabetes mellitus and play a role in healthier aging? J Am Geriatr Soc, 59(10): 1957-1959.
  • Forman JP, Curhan GC, Taylor EN (2008) Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension, 52(5): 828-832.
  • Forman JP, Bischoff-Ferrari HA, Willett WC et al. (2005) Vitamin D intake and risk of incident hypertension prospective cohort studies. Hypertension, 46(4): 676-682. from three large
  • Forman JP, Giovannucci E, Holmes MD et al. (2007) Plasma 25-Hydroxyvitamin D levels and risk of incident hypertension. Hypertension, 49(5): 1063-1069. (doi: 10.1161/Hypertensı- onaha.107.087288).
  • Goel LK, Lal H (2011) Role of vitamin D supple- mentation in hypertension. Indian J Clin Biochem, 26(1): 88–90.
  • Grant WB, Holick MF (2005) Benefits and requirements of vitamin D for optimal health: A review. Altern Med Rev, 10(2): 94-111.
  • Holick M (2008) Diabetes and the vitamin D connection. Current Diabetes Reports, 8(5): 393-398.
  • Holick MF (2013) The D-lightful vitamin D for health. J Med Biochem, 32(1): 1-10.
  • Jafari T, Paknahad Z (2014) Vitamin D and Hypertension. Zahedan J Res Med Sci, 16(6): 1-7.
  • Jameson JL, Weetman AP (2004) Tiroid bezi hastalıkları. (Çeviri editörü: Y. Sağlıker). Harrison İç Hastalıkları Prensipleri (15. Edisyon). Nobel Matbaacılık, İstanbul, s:2060- 2075.
  • Javed R, Malik SY, Yaqup S et al. (2012) Levels of 25-OH vitamin D in healthy asymptomatic adults: Pilot study. Pak J Med Res, July- September: 82-86.
  • Kavaric S, Vuksanovic M, Bozovic D et al. (2013) Body weight and waist circumference as predictors of vitamin D deficiency in patients with type 2 diabetes and cardiovascular disease. Vojnosanit Pregl, 70(2): 163-169.
  • Kim MK, Kang M, Won Oh K et al. (2010) The association of serum vitamin D level with presence of metabolic syndrome and hyperteso n in middle-aged Endocrinol (Oxf), 73(3): 330-338. Clin
  • Kota SK, Kota SK, Jammula S et al. (2011) Renin- angiotensin system activity in vitamin D defici ent, obese individuals with hypertension:An ur ban Indian study. Indian J Endocrinol Metab, 15(4): 395-401.
  • Kurşun ÖS (2008) Şişman çocuklarda D vitamini düzeyleri ve insülin direnci ile ilişkisinin araştırılması. Yayımlanmamış uzmanlık tezi, Trakya Üniversitesi Tıp Fakültesi, Edirne.
  • Kunutsor SK, Apekey TA (2013) Vitamin D and risk of future hypertension: Meta-analysis of 283.537 participants. Eur J Epidemiol, 28(3): 205-221. (DOI: 10.1007/s10654-013-9790-2).
  • Li YC, Qiao G, Uskokovic M et al. (2004) Vitamin D: A negative endocrine regulator of the renin– angiotensin system and blood pressure. J Ster Bio -chem Molec Biol, 89–90:387–392.
  • Lim S, Kim MJ, Choi SH t al. (2013) Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asiansubjects. Am J Clin Nutr, 97(3): 524-530.
  • Martin T, Campbell K (2011) Vitamin D and diabetes. Diabetes Spectrum, 24(2): 113-118.
  • Maxwell CS, Wood RJ (2011) Update on vitamin D and type 2 diabetes. Nutrition Reviews, 69(5): 291-295.
  • Mitri J, Muraru MD, Pittas AG (2011) Vitamin D and type 2 diabetes: a systematic review. European Journal of Clinical Nutrition, 65(9): 1005-1015.
  • Özkan B, Döneray H (2011) D vitamininin iskelet sistemi dışı etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi, 54(2): 99-119.
  • Parker J, Hashmi O, Dutton D et al. (2010) Levels of vitamin D and cardiometabolic disorders: Systematic Maturitas, 65(3): 225-236. meta-analysis.
  • Pavlovic D, Josipovic J, Pavlovic N (2011) Vitamin D and hypertension. Periodicum Biologorum, 113(3) :299-302.
  • Pearce SH, Cheetham TD (2010) Diagnosis and management of vitamin D deficiency. BMJ, 340.
  • Snijder MB, Lips P, Seidell JC et al. (2007) Vitamin D status and parathyroid hormone levels in relation to blood pressure: A population-based study in older men and women. J Intern Med, 261(6): 558-565.
  • Sung CC, Liao MT, Lu KC et al. (2012) Role of vitamin D in insulin resistance. Journal of Biomedicine and Biotechnology, Article ID 634195 (doi:10.1155/2012/634195).
  • Tamez H, Kalim S, Thadhani RI (2013) Does vitamin D modulate blood pressure?. Clinical Nephrology, 22(2): 204-209.
  • Tellioğlu A, Başaran S (2013) Güncel bilgiler ışığında vitamin D. Arşiv Kaynak Tarama Dergisi, 22(2): 259-271.
  • Ullah MI, Uwaifo GI, Nicholas WC et al. (2010) Does vitamin d deficiency cause hypertension? Current evidence from clinical studies and pot entialmechanisms.Int J Endocrinol. 2010: 579640.
  • Vacek JL, Vanga SR, Good M et al. (2012) Vitamin D deficiency and supplementation and relation to cardiovascular health. Am J Cardiol, 109:359–363.
  • Wang TJ, Pencina MJ, Booth SL et al. (2008) deficiency cardiovascular disease. Circulation, 117:503- 511. and risk of
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makalesi
Yazarlar

Azime Karakoç Kumsar

Feride Taşkın Yılmaz

Nermin Olgun

Yayımlanma Tarihi 10 Temmuz 2015
Yayımlandığı Sayı Yıl 2015Cilt: 4 Sayı: 1

Kaynak Göster

APA Karakoç Kumsar, A., Taşkın Yılmaz, F., & Olgun, N. (2015). VİTAMİN D EKSİKLİĞİ HİPERTANSİYON GELİŞİMİNDE BİR RİSK FAKTÖRÜ MÜ?. Cumhuriyet Hemşirelik Dergisi, 4(1), 34-39.